Syringe Filling Machine Manufacturers

In the world of pharmaceutical manufacturing, precision and reliability are non-negotiable. That’s why syringe filling machine manufacturers are committed to rigorous testing procedures and unparalleled expertise.

Syringe filling machines can accommodate nested ready-to-use syringe formats as well as vials and cartridges. They can also perform through-the-tip filling and gassing of oxygen sensitive drugs.

Downward Filling

Whether you’re washing your hair, making a peanut butter and jelly sandwich or feeding your pet kibble, filling machines play an integral part in our everyday lives. But how do they work? When you press the foot pedal on a linear machine, an exact quantity of product is drawn from the hopper and dispensed into the container. This type of volumetric system is ideal for thick liquids and pastes.

A piston filler utilizes a stroke and discharge system to move a predetermined amount of product into the container from a piston chamber. The system works by drawing the product down into a cup-like funnel which then releases it. This method is popular for high-viscous products and is often found in semi-automatic machines.

If you’re looking syringe filling machine to handle free-flowing powders, you can use a net weight filler to weigh the product prior to filling. These systems are slower than augers and cups, but offer consistency in powder-based products.

Linear fillers are great for businesses that need a reliable, easy-to-use machine. They also offer a lower cost and can easily scale with production demands. However, they don’t deliver the same speed that rotary machines can and often require specialised repair technicians. They’re perfect for smaller companies or those looking for a more cost-effective solution.

Vacuum Placement

Our automated syringe filling machine offers a fully sanitary design, ensuring that only high-quality materials are used. It uses a combination of mechanical placement and precise vacuum control to reduce or eliminate air bubbles within the syringe. This method allows for void-free, accurate, and consistent syringe filling that meets your precise specifications. It also provides the ideal solution for two-component materials like epoxies and composite resins.

Our syringe filling machine is designed to operate in a gloveless robotic isolator and is capable of processing bulk aseptic syringes, vials, or cartridges. It can even be fitted with a rod inserter and labeler to process complex, multi-dose prefilled syringes for drug distribution. Our syringe filling machines are the perfect choice for performance demanding customers in the pharmaceutical, biotech, and veterinary industries.

Depending on the desired level of control, these syringe filling machines can be fitted with either a statistical or 100% In-Process-Control (IPC) system. In the former, objects remain in the nest during the whole filling and stoppering process while in the latter, they are lifted out of the nest, weighed and inspected before and after the operation. The weighing process is completely integrated into the machine and is controlled by a computer. This guarantees the highest quality of your product and helps to prevent Repetitive Stress Injury (RSI). Using a syringe filling machine to aseptically fill nested RTU syringes, vials or cartridges increases production rates in the medical industry while providing increased sterility assurance compared with manual methods.

Mechanical Assist

Heart failure is an increasingly common medical condition that afflicts millions of people worldwide. If the condition is severe enough that the heart cannot effectively pump blood and function suffers, this is known as cardiogenic shock and patients are at very high risk of death (Lu 2016).

Mechanical support devices such as a continuous-flow mechanical circulatory assist device can temporarily improve cardiac functioning by helping to unload the failing ventricle. This reduces pulmonary congestion, myocardial wall stress and myocardial oxygen consumption. These syringe filling machine company devices can also be used during procedures that aim to treat the cause of the heart failure which leads to cardiogenic shock such as coronary artery bypass surgery (CABG) or ablation of ventricular arrhythmias.

However, a meta-analysis of five studies with a total of 162 patients found that these devices have no impact on 30-day survival (RR 0.76 95% CI 0.76 to 1.01) and there is very low confidence in the evidence. Therefore, ED and ICU staff should have a thorough understanding of the evidence for these devices and how they are used to support patients who are in cardiac shock. This includes knowing when a device may be inappropriate, e.g. in a patient who has had a myocardial infarction and is in shock due to recurrent ischemia.

Suckback Control

Syringes represent a growing drug delivery platform with an inherently challenging, precision-dependent product filling process. This niche requires advanced automation technologies to ensure a highly consistent, quality-driven production process.

The ideal prefilled syringe filling machine is designed to produce accurate, high-performing syringes that are both sterile and easy to inspect and handle. As such, it must prioritize flexibility in order to accommodate different container types and closures.

This is especially important when it comes to dual-chamber syringes or high viscosity drugs that may require special handling. For this reason, a versatile automated syringe filling system should be “filling agnostic,” capable of producing a variety of different volumes using various methods (including rotary piston, peristaltic pump, and direct draw from reservoir bag).

Additionally, syringe filling machines featuring a simple design for faster cleaning and maintenance are preferred. This minimizes risk of air bubble entrapment and prevents material contamination, ensuring high-quality product and accurate filling. Moreover, machines that offer mechanical assist and increased control of vacuum levels eliminate the potential for slip-stoppering errors. They also allow for faster, more precise rod insertion and label application, delivering a streamlined workflow that maximizes efficiencies. Lastly, these syringe filling machines should be able to fit under a laminar flow hood for aseptic filling. This is especially critical for glycerol and other solvent-based drugs that must be stored at low temperatures.